Immunogen
Purified recombinant fragment of human Pirh2 expressed in E. Coli.
Specificity
Pirh2 Monoclonal Antibody detects endogenous levels of Pirh2 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013],
Function
similarity:Contains 1 CHY-type zinc finger.,similarity:Contains 1 CTCHY-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with AR, PLAG1 and SCYL1BP1/NTKLBP1.,
Protein name
RING finger and CHY zinc finger domain-containing protein 1
Other name
RCHY1; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; RING finger and CHY zinc finger domain-containing protein 1; Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger
Fields
>>p53 signaling pathway;>>Ubiquitin mediated proteolysis;>>Measles
Human protein sequence Database
Q96PM5
Mouse protein sequence database
Q9CR50
Rat protein sequence database
Cellular localization
Nucleus. Nucleus speckle. Cytoplasm.
Tissue expression
Liver,Platelet,Skin,Uterus,
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成功添加到购物车