Molecular weight (DA)
46kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RAD52 around the phosphorylation site of Tyr104. AA range:70-119
Specificity
Phospho-Rad52 (Y104) Polyclonal Antibody detects endogenous levels of Rad52 protein only when phosphorylated at Y104.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014],
Function
function:Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the RAD52 family.,subunit:Forms a undecameric ring.,
Protein name
DNA repair protein RAD52 homolog
Other name
RAD52; DNA repair protein RAD52 homolog
Fields
>>Homologous recombination
Human protein sequence Database
P43351
Mouse protein sequence database
P43352
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Amygdala,Brain,Embryonal rhabdomyosarcoma,Hippocampus,PCR rescued c
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