Molecular weight (DA)
106kD
Immunogen
The antiserum was produced against synthesized peptide derived from human BCLAF1. AA range:281-330
Specificity
BTF Polyclonal Antibody detects endogenous levels of BTF protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:Death-promoting transcriptional repressor.,sequence caution:Contaminating sequence. Potential poly-A sequence.,subunit:Interacts with Bcl-2 related proteins, EMD, with the adenovirus E1B 19 kDa protein and with DNA.,tissue specificity:Ubiquitous.,
Protein name
Bcl-2-associated transcription factor 1
Other name
BCLAF1; BTF; KIAA0164; Bcl-2-associated transcription factor 1; Btf
Human protein sequence Database
Q9NYF8
Mouse protein sequence database
Q8K019
Rat protein sequence database
Cellular localization
Cytoplasm. Nucleus. Nucleus speckle . Nucleus, nucleoplasm .
Tissue expression
Ubiquitous.
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