Molecular weight (DA)
133kD
Immunogen
The antiserum was produced against synthesized peptide derived from human DNL1. AA range:111-160
Specificity
DNA Ligase I Polyclonal Antibody detects endogenous levels of DNA Ligase I protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
Function
catalytic activity:ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).,cofactor:Magnesium.,disease:Defects in LIG1 seem to cause immunodeficiencies and cellular hypersensitivity to DNA-damaging agents.,function:DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.,online information:DNA ligase entry,online information:LIG1 mutation db,similarity:Belongs to the ATP-dependent DNA ligase family.,
Protein name
DNA ligase 1
Abbreviation
DNA Ligase I
Other name
LIG1; DNA ligase 1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1
Fields
>>DNA replication;>>Base excision repair;>>Nucleotide excision repair;>>Mismatch repair
Human protein sequence Database
P18858
Mouse protein sequence database
P37913
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Brain,Epithelium,Eye,PCR rescued clones,T lymphoblast,
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