Molecular weight (DA)
61kD
Immunogen
The antiserum was produced against synthesized peptide derived from human FAST. AA range:361-410
Specificity
FAST Polyclonal Antibody detects endogenous levels of FAST protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein].,function:Fas-mediated apoptosis is characterized by FASTK-dephosphorylation and TIA-1-phosphorylation. Both are activated and FASTK-mediated TIA-1 activation play a key role in apoptosis.,PTM:Phosphorylated on serine/threonine.,similarity:Belongs to the FAST protein kinase family.,similarity:Contains 1 RAP domain.,subunit:Interacts with TIA-1.,tissue specificity:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
Protein name
Fas-activated serine/threonine kinase
Other name
FASTK; Fas-activated serine/threonine kinase; FAST kinase
Human protein sequence Database
Q14296
Mouse protein sequence database
Q9JIX9
Rat protein sequence database
Cellular localization
[Isoform 4]: Mitochondrion matrix . Colocalizes with mitochondrial RNA granules. .
Tissue expression
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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