Molecular weight (DA)
20kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PTTG. AA range:116-165
Specificity
PBF Polyclonal Antibody detects endogenous levels of PBF protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013],
Function
function:May facilitate PTTG1 nuclear translocation.,induction:By transcription factor RUNX2.,subcellular location:According to PubMed:10781616 it is found in the cytoplasm and the nucleus.,subunit:Interacts with PTTG1.,tissue specificity:Ubiquitous.,
Protein name
Pituitary tumor-transforming gene 1 protein-interacting protein
Other name
PTTG1IP; C21orf1; C21orf3; Pituitary tumor-transforming gene 1 protein-interacting protein; Pituitary tumor-transforming gene protein-binding factor; PBF; PTTG-binding factor
Human protein sequence Database
P53801
Mouse protein sequence database
Q8R143
Rat protein sequence database
Q6P767
Cellular localization
Membrane ; Single-pass type I membrane protein . Cytoplasm . Nucleus . According to PubMed:10781616, it is found in the cytoplasm and the nucleus.
Tissue expression
Ubiquitous.
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