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Rad54 Polyclonal Antibody

Polyclonal antibody

Specification

BYab-00515

  • 50UL $180 100UL $255
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Host
Reactiveness
Use
Molecular weight (DA)
85kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RAD54L. AA range:221-270
Specificity
Rad54 Polyclonal Antibody detects endogenous levels of Rad54 protein.
Source
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Background
The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008],
Function
disease:Defects in RAD54L may be a cause of tumor formation. Although alterations are found in a small fraction of primary tumors, these findings provide new insight into genetic instability underlying carcinogenesis.,function:Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells.,induction:Expression increases approximately 3-fold in late G1 phase compared to other phases of the cell cycle.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subunit:Interacts with RAD51 through the N
Gene Name
RAD54L
Protein name
DNA repair and recombination protein RAD54-like
Abbreviation
Rad54
Other name
RAD54L; RAD54A; DNA repair and recombination protein RAD54-like; RAD54 homolog; hHR54; hRAD54
Fields
>>Homologous recombination
Human gene ID
8438
Human protein sequence Database
Q92698
Mouse gene ID
19366
Mouse protein sequence database
P70270
Rat gene ID
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Testis,Thymus,
Storage
-20°C/1 year

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Rad54 Polyclonal Antibody

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