Molecular weight (DA)
28kD
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human BRMS1. AA range:197-246
Specificity
BRMS-1 Polyclonal Antibody detects endogenous levels of BRMS-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Function
function:May be a mediator of metastasis suppression in breast carcinoma.,similarity:Belongs to the BRMS1 family.,tissue specificity:Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.,
Protein name
Breast cancer metastasis-suppressor 1
Other name
BRMS1; Breast cancer metastasis-suppressor 1
Human protein sequence Database
Q9HCU9
Mouse protein sequence database
Q99N20
Rat protein sequence database
Q5M7T3
Cellular localization
Nucleus. Cytoplasm. Predominantly nuclear.
Tissue expression
Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.
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