Molecular weight (DA)
100kD
Immunogen
The antiserum was produced against synthesized peptide derived from human DYN1 around the phosphorylation site of Ser778. AA range:751-800
Specificity
Phospho-Dynamin I (S778) Polyclonal Antibody detects endogenous levels of Dynamin I protein only when phosphorylated at S778.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
dynamin 1(DNM1) Homo sapiens This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
Function
catalytic activity:GTP + H(2)O = GDP + phosphate.,function:Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.,similarity:Belongs to the dynamin family.,similarity:Contains 1 GED domain.,similarity:Contains 1 PH domain.,subcellular location:Microtubule-associated.,subunit:Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3.,
Other name
DNM1; DNM; Dynamin-1
Fields
>>Phospholipase D signaling pathway;>>Endocytosis;>>Synaptic vesicle cycle;>>Endocrine and other factor-regulated calcium reabsorption;>>Bacterial invasion of epithelial cells
Human protein sequence Database
Q05193
Mouse protein sequence database
P39053
Rat protein sequence database
P21575
Cellular localization
Cytoplasm . Cytoplasm, cytoskeleton . Microtubule-associated.
Tissue expression
Brain,Platelet,PNS,
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