Molecular weight (DA)
185kD
Immunogen
Synthesized peptide derived from ABCA6 . at AA range: 1180-1260
Specificity
ABCA6 Polyclonal Antibody detects endogenous levels of ABCA6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24 and may play a role in macrophage lipid homeostasis. [provided by RefSeq, Jul 2008],
Function
developmental stage:Expressed in fetal kidney, lung and liver.,function:Probable transporter which may play a role in macrophage lipid homeostasis.,induction:Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages.,similarity:Belongs to the ABC transporter family. ABCA subfamily.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Widely expressed with higher expression in liver.,
Protein name
ATP-binding cassette sub-family A member 6
Other name
ABCA6; ATP-binding cassette sub-family A member 6
Fields
>>ABC transporters
Human protein sequence Database
Q8N139
Mouse protein sequence database
Q8K441
Rat protein sequence database
Cellular localization
Golgi apparatus membrane ; Multi-pass membrane protein .
Tissue expression
Widely expressed with higher expression in liver.
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