Molecular weight (DA)
79kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ABCB10. AA range:441-490
Specificity
ABCB10 Polyclonal Antibody detects endogenous levels of ABCB10 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008],
Function
function:May mediate critical mitochondrial transport functions related to heme biosynthesis.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.,similarity:Contains 1 ABC transmembrane type-1 domain.,similarity:Contains 1 ABC transporter domain.,subunit:Homodimer or heterodimer .,tissue specificity:Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon.,
Protein name
ATP-binding cassette sub-family B member 10 mitochondrial
Other name
ABCB10; ATP-binding cassette sub-family B member 10; mitochondrial; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2
Fields
>>ABC transporters
Human protein sequence Database
Q9NRK6
Mouse protein sequence database
Q9JI39
Rat protein sequence database
Cellular localization
Mitochondrion inner membrane ; Multi-pass membrane protein .
Tissue expression
Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon.
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