Molecular weight (DA)
95kD
Immunogen
Synthesized peptide derived from ABCF1 . at AA range: 760-840
Specificity
ABCF1 Polyclonal Antibody detects endogenous levels of ABCF1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008],
Function
function:May function in mRNA translation.,induction:By TNF (in cultured synoviocytes).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. EF3 subfamily.,similarity:Contains 2 ABC transporter domains.,subunit:Interacts with eukaryotic initiation factor 2 (eIF2). Associates with the ribosomes.,tissue specificity:Ubiquitous.,
Protein name
ATP-binding cassette sub-family F member 1
Other name
ABCF1; ABC50; ATP-binding cassette sub-family F member 1; ATP-binding cassette 50; TNF-alpha-stimulated ABC protein
Human protein sequence Database
Q8NE71
Mouse protein sequence database
Q6P542
Rat protein sequence database
Q6MG08
Cellular localization
[Isoform 2]: Cytoplasm . Nucleus, nucleoplasm . Nucleus envelope .
Tissue expression
Ubiquitous.
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