Molecular weight (DA)
76kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SYTL4. AA range:381-430
Specificity
Granuphilin Polyclonal Antibody detects endogenous levels of Granuphilin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010],
Function
function:Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 RabBD (Rab-binding) domain.,similarity:Contains 2 C2 domains.,subcellular location:Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles.,subunit:Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B.,
Protein name
Synaptotagmin-like protein 4
Other name
SYTL4; Synaptotagmin-like protein 4; Exophilin-2; Granuphilin
Human protein sequence Database
Q96C24
Mouse protein sequence database
Q9R0Q1
Rat protein sequence database
Q8VHQ7
Cellular localization
Membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein . Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity). .
Tissue expression
Adrenal gland,Endometrium,Epithelium,Platelet,Spinal cord,Testis,Uterus,
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