Molecular weight (DA)
75kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SGLT-1. AA range:525-574
Specificity
SGLT-1 Polyclonal Antibody detects endogenous levels of SGLT-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
Function
disease:Defects in SLC5A1 are the cause of congenital glucose/galactose malabsorption (GGM) [MIM:606824]. GGM is an intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet.,function:Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.,PTM:N-glycosylation is not necessary for the cotransporter function.,similarity:Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.,tissue specificit
Protein name
Sodium/glucose cotransporter 1
Other name
SLC5A1; NAGT; SGLT1; Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1
Fields
>>Carbohydrate digestion and absorption;>>Bile secretion;>>Mineral absorption
Human protein sequence Database
P13866
Mouse protein sequence database
Q8C3K6
Rat protein sequence database
P53790
Cellular localization
Apical cell membrane ; Multi-pass membrane protein .
Tissue expression
Expressed in intestine (PubMed:2490366). Expressed in endometrial cells (PubMed:28974690).
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