Molecular weight (DA)
23kD
Immunogen
The antiserum was produced against synthesized peptide derived from human VTI1A. AA range:31-80
Specificity
v-SNARE Vti1a Polyclonal Antibody detects endogenous levels of v-SNARE Vti1a protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
Function
function:V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.,similarity:Belongs to the VTI1 family.,
Protein name
Vesicle transport through interaction with t-SNAREs homolog 1A
Abbreviation
v-SNARE Vti1a
Other name
VTI1A; Vesicle transport through interaction with t-SNAREs homolog 1A; Vesicle transport v-SNARE protein Vti1-like 2; Vti1-rp2
Fields
>>SNARE interactions in vesicular transport
Human protein sequence Database
Q96AJ9
Mouse protein sequence database
O89116
Rat protein sequence database
Q9JI51
Cellular localization
Cytoplasmic vesicle . Golgi apparatus membrane ; Single-pass type IV membrane protein .
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