Immunogen
Synthesized peptide derived from human RBP AA range: 11-60
Specificity
This antibody detects endogenous levels of Human RBP
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
retinol binding protein 4(RBP4) Homo sapiens This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008],
Function
disease:A deficiency of vitamin A blocks secretion of the binding protein post-translationally and results in defective delivery and supply of vitamin to the epidermal cells (a condition associated with a dermatosis).,disease:Defects in RBP4 are a cause of retinol-binding protein deficiency [MIM:180250]. This condition causes night vision problems. It produces a typical "fundus xerophthalmicus," featuring a progressed atrophy of the retinal pigment epithelium.,function:Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.,mass spectrometry: PubMed:12237133,mass spectrometry: PubMed:7666002,online information:Retina International's Scientific Newsletter,online information:Retinol-binding protein 4 entry,similarity:Belongs to the calycin superfamil
Other name
Retinol-binding protein 4 (Plasma retinol-binding protein;PRBP;RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)]
Human protein sequence Database
P02753
Mouse protein sequence database
Q00724
Rat protein sequence database
P04916
Cellular localization
Secreted .
Tissue expression
Detected in blood plasma and in urine (at protein level).
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