Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized Acetyl-peptide derived from human FOXA1 around the Acetylation site of Lys265. AA range:231-280
Specificity
Acetyl-HNF-3α/β/γ (K264/253/211) Polyclonal Antibody detects endogenous levels of HNF-3α/β/γ protein only when acetylated at K264/253/211.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008],
Function
function:Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes.,online information:Hepatocyte nuclear factors entry,similarity:Contains 1 fork-head DNA-binding domain.,
Gene Name
FOXA1/FOXA2/FOXA3
Protein name
Hepatocyte nuclear factor 3-alpha/Hepatocyte nuclear factor 3-beta/Hepatocyte nuclear factor 3-gamma
Other name
FOXA1; HNF3A; TCF3A; Hepatocyte nuclear factor 3-alpha; HNF-3-alpha; HNF-3A; Forkhead box protein A1; Transcription factor 3A; TCF-3A; FOXA2; HNF3B; TCF3B; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B;Forkhead box protein A2; Transcription factor 3B; TCF-3B; FOXA3; HNF3G; TCF3G; Hepatocyte nuclear factor 3-gamma; HNF-3-gamma; HNF-3G; Fork head-related protein FKH H3; Forkhead box protein A3; Transcription factor 3G; TCF-3G
Human protein sequence Database
P55317
Mouse protein sequence database
P35582
Rat protein sequence database
P23512
Cellular localization
Nucleus .
Tissue expression
Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.
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