Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from human DNA pol β (Acetyl Lys72)
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat DNA pol β (Acetyl Lys72)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Binds 2 magnesium ions per subunit.,domain:Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.,function:Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.,PTM:Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.,similarity:Belongs to the DNA polymerase type-X family.,subunit:Monomer.,
Function
DNA metabolic process, DNA replication, DNA-dependent DNA replication, DNA repair, base-excision repair, pyrimidine dimer repair, anti-apoptosis, response to DNA damage stimulus, cell death, regulation of cell death, death, cellular response to stress, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death,negative regulation of programmed cell death, negative regulation of cell death,
Protein name
DNA pol β (Acetyl Lys72)
Other name
DNA polymerase beta (EC 2.7.7.7;EC 4.2.99.-)
Fields
>>Base excision repair;>>Human T-cell leukemia virus 1 infection;>>Viral carcinogenesis
Human protein sequence Database
P06746
Mouse protein sequence database
Q8K409
Rat protein sequence database
P06766
Cellular localization
Nucleus. Cytoplasm. Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车