Molecular weight (DA)
73kD
Immunogen
Synthesized peptide derived from human Stat2 (Acetyl Lys384)
Specificity
This antibody detects endogenous levels of Human,Rat Stat2 (Acetyl Lys384)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
function:Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.,PTM:Tyrosine phosphorylated in response to IFN-alpha.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus upon activation by IFN-alpha/beta.,subunit:Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein.,
Function
transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,intracellular signaling cascade, protein kinase cascade, JAK-STAT cascade, response to virus, regulation of transcription, regulation of RNA metabolic process,
Protein name
Stat2 (Acetyl Lys384)
Other name
Signal transducer and activator of transcription 2 (p113)
Fields
>>Chemokine signaling pathway;>>Necroptosis;>>Osteoclast differentiation;>>NOD-like receptor signaling pathway;>>C-type lectin receptor signaling pathway;>>JAK-STAT signaling pathway;>>Hepatitis C;>>Hepatitis B;>>Measles;>>Influenza A;>>Human papillomavirus infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Coronavirus disease - COVID-19;>>Pathways in cancer
Human protein sequence Database
P52630
Mouse protein sequence database
Q9WVL2
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Translocated into the nucleus upon activation by IFN-alpha/beta. .
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