Immunogen
Purified recombinant fragment of BHMT expressed in E. Coli.
Specificity
BHMT Monoclonal Antibody detects endogenous levels of BHMT protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
Affinity purification
Background
betaine--homocysteine S-methyltransferase(BHMT) Homo sapiens This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.,cofactor:Binds 1 zinc ion per subunit.,function:Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.,pathway:Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.,pathway:Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.,similarity:Contains 1 Hcy-binding domain.,subunit:Homotetramer.,tissue specificity:Found exclusively in liver and kidney.,
Protein name
Betaine--homocysteine S-methyltransferase 1
Other name
BHMT; Betaine--homocysteine S-methyltransferase 1
Fields
>>Glycine, serine and threonine metabolism;>>Cysteine and methionine metabolism;>>Metabolic pathways
Human protein sequence Database
Q93088
Mouse protein sequence database
O35490
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Nucleus . Predominantly localized in the cytoplasm with a small fraction detected in the nucleus. Translocates into the nucleus upon oxidative stress. .
Tissue expression
Found exclusively in liver and kidney.
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