Immunogen
Purified recombinant fragment of human Msi1 expressed in E. Coli.
Specificity
Msi1 Monoclonal Antibody detects endogenous levels of Msi1 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008],
Function
domain:The first RNA recognition motif binds more strongly to RNA compared to the second one.,function:RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.,similarity:Belongs to the Musashi family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,tissue specificity:Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.,
Protein name
RNA-binding protein Musashi homolog 1
Other name
MSI1; RNA-binding protein Musashi homolog 1; Musashi-1
Fields
>>mRNA surveillance pathway
Human protein sequence Database
O43347
Mouse protein sequence database
Q61474
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus .
Tissue expression
Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.
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