Immunogen
Purified recombinant fragment of human Msi2 expressed in E. Coli.
Specificity
Msi2 Monoclonal Antibody detects endogenous levels of Msi2 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
Affinity purification
Background
This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016],
Function
disease:Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).,function:RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.,induction:Up-regulated in astrocytes after brain injury.,PTM:Phosphorylated.,similarity:Belongs to the Musashi family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subcellular location:Associated with polysomes.,tissue specificity:Ubiquitous; detected at low levels.,
Protein name
RNA-binding protein Musashi homolog 2
Other name
MSI2; RNA-binding protein Musashi homolog 2; Musashi-2
Fields
>>mRNA surveillance pathway
Human protein sequence Database
Q96DH6
Mouse protein sequence database
Q920Q6
Rat protein sequence database
Cellular localization
Cytoplasm. Associated with polysomes. .
Tissue expression
Ubiquitous; detected at low levels.
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