Immunogen
Purified recombinant fragment of human THAP11 expressed in E. Coli.
Specificity
THAP11 Monoclonal Antibody detects endogenous levels of THAP11 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008],
Function
function:Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers.,polymorphism:The length of the poly-Gln region is variable in the population.,similarity:Belongs to the THAP11 family.,similarity:Contains 1 THAP-type zinc finger.,subcellular location:May be regulated by shuttling of the protein between the cytoplasm and nucleus.,subunit:Interacts (via coiled coil domain) with HCFC1.,
Protein name
THAP domain-containing protein 11
Other name
THAP11; HRIHFB2206; THAP domain-containing protein 11
Human protein sequence Database
Q96EK4
Mouse protein sequence database
Q9JJD0
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . May be regulated by shuttling of the protein between the cytoplasm and nucleus. .
Tissue expression
Brain,Neuroblastoma,Uterus,
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