Immunogen
Purified recombinant fragment of TudorSN (aa361-485) expressed in E. Coli.
Specificity
TudorSN Monoclonal Antibody detects endogenous levels of TudorSN protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016],
Function
function:Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).,PTM:Phosphorylated by PIM1 in vitro.,sequence caution:The frameshift leads to wrong initation.,similarity:Contains 1 Tudor domain.,similarity:Contains 4 TNase-like domains.,subcellular location:In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Binds to acidic transactivation domain of EBNA2. Interacts with EAV NSP1. Interacts with GTF2E1 and GTF2E2. Forms a ternary complex with STAT6 and POLR2A. Interacts with STAT5.,tissue specificity:Ubiquitously expressed.,
Protein name
Staphylococcal nuclease domain-containing protein 1
Other name
SND1; TDRD11; Staphylococcal nuclease domain-containing protein 1; 100 kDa coactivator; EBNA2 coactivator p100; Tudor domain-containing protein 11; p100 co-activator
Fields
>>Viral carcinogenesis
Human protein sequence Database
Q7KZF4
Mouse protein sequence database
Q78PY7
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Melanosome . In IL-4 stimulated cells colocalizes with STAT6 in the nucleus (PubMed:12234934). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
Tissue expression
Ubiquitously expressed.
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