Molecular weight (DA)
56kD
Immunogen
Purified recombinant human NFIC protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of NFIC and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb 1:200 icc 1:200
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011],
Function
function:Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.,similarity:Belongs to the CTF/NF-I family.,similarity:Contains 1 CTF/NF-I DNA-binding domain.,subunit:Binds DNA as a homodimer.,
Other name
1110019L22Rik;1500041O16Rik;AA589446;AI746521;CAAT box transcription factor;CCAAT binding transcription factor;CCAAT box binding transcription factor;CCAAT-box-binding transcription factor;CNFI C;CTF;CTF5;MGC137374;MGC20153;NF I;NF I/C;NF-I/C;NF1 C;NF1-C; NF1C;NFI;NFI-C;NFI/C;NFIC;NFIC_HUMAN;Nuclear factor 1;Nuclear factor 1 C type;Nuclear factor 1 C-type;Nuclear factor 1/C;Nuclear factor I/C;TGGCA binding protein;TGGCA-binding protein;Transcription factor NFIC.
Human protein sequence Database
P08651
Mouse protein sequence database
P70255
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Epithelium,Uterus,
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