Molecular weight (DA)
160kD
Immunogen
Purified recombinant human LRRFIP1 protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of LRRFIP1 and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
developmental stage:Widely expressed in fetal tissues.,function:Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the LRRFIP family.,subunit:Interacts with FLII.,tissue specificity:Ubiquitously expressed.,
Function
developmental stage:Widely expressed in fetal tissues.,function:Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the LRRFIP family.,subunit:Interacts with FLII.,tissue specificity:Ubiquitously expressed.,
Other name
FLAP1;FLIIAP 1;GC binding factor 2;GCF2;HUFI1;Leucine rich repeat (in FLII) interacting protein 1;Leucine rich repeat flightless interacting protein 1;LRR FLII interacting protein 1;LRRFIP 1;Lrrfip1;MGC10947;MGC119738;MGC119739;NEDD8 conjugating enzyme;TAR RNA interacting protein;TAR RNA-interacting protein;Transcription factor 9 like;TRIP.
Human protein sequence Database
Q32MZ4
Mouse protein sequence database
Q3UZ39
Rat protein sequence database
Cellular localization
Nucleus. Cytoplasm.
Tissue expression
Ubiquitously expressed.
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