Molecular weight (DA)
55kD
Immunogen
Recombinant Protein of β-tubulin (HRP Conjugated)
Specificity
Theβ-tubulin antibody can detects endogenousβ-tubulin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1:1000-1:3000,IHC: 1:50-1:200 IF 1:200
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014],
Function
domain:The highly acidic C-terminal region may bind cations such as calcium.,function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,online information:Tubulin entry,similarity:Belongs to the tubulin family.,subunit:Dimer of alpha and beta chains.,tissue specificity:Ubiquitously expressed with highest levels in spleen, thymus and immature brain.,
Protein name
Tubulin beta chain (Tubulin beta-5 chain)
Other name
Tubulin beta chain (Tubulin beta-5 chain)
Fields
>>Phagosome;>>Gap junction;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Pathogenic Escherichia coli infection;>>Salmonella infection
Human protein sequence Database
P07437
Mouse protein sequence database
P99024
Rat protein sequence database
P69897
Cellular localization
Cytoplasm, cytoskeleton .
Tissue expression
Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
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