Molecular weight (DA)
150kD
Immunogen
Synthetic Peptide of SLC12A4 AA range: 658-708
Specificity
SLC12A4 protein(A248) detects endogenous levels of SLC12A4
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013],
Function
alternative products:Experimental confirmation may be lacking for some isoforms,function:Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.,PTM:N-glycosylated.,similarity:Belongs to the SLC12A transporter family.,subunit:Homomultimer and heteromultimer with other K-Cl cotransporters.,tissue specificity:Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.,
Protein name
Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1)
Other name
Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1;Erythroid K-Cl cotransporter 1;hKCC1)
Human protein sequence Database
Q9UP95
Mouse protein sequence database
Q9JIS8
Rat protein sequence database
Q63632
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车