Molecular weight (DA)
52kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SRF around the phosphorylation site of Ser77. AA range:41-90
Specificity
Phospho-SRF (S77) Polyclonal Antibody detects endogenous levels of SRF protein only when phosphorylated at S77.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014],
Function
function:SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentation and maturation.,PTM:Phosphorylated by PRKDC.,similarity:Contains 1 MADS-box domain.,subunit:Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1 (By similarity). Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1.,
Protein name
Serum response factor
Other name
SRF; Serum response factor; SRF
Fields
>>MAPK signaling pathway;>>cGMP-PKG signaling pathway;>>Human T-cell leukemia virus 1 infection;>>Viral carcinogenesis
Human protein sequence Database
P11831
Mouse protein sequence database
Q9JM73
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Brain,Epithelium,Lung,Lymph,
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