Immunogen
The antiserum was produced against synthesized peptide derived from human Myb around the phosphorylation site of Ser532. AA range:496-545
Specificity
Phospho-c-Myb (S532) Polyclonal Antibody detects endogenous levels of c-Myb protein only when phosphorylated at S532.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
Function
domain:Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.,function:Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.,PTM:Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.,PTM:Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,similarity:Contains 3 HTH myb-type DNA-binding domains.,subunit:Binds MYBBP1A. Interacts with HIPK2, MAF and NLK.,
Protein name
Transcriptional activator Myb
Other name
MYB; Transcriptional activator Myb; Proto-oncogene c-Myb
Fields
>>PI3K-Akt signaling pathway
Human protein sequence Database
P10242
Mouse protein sequence database
P06876
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Liver,Placenta,Testis,
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