Molecular weight (DA)
17-25kD
Immunogen
Synthetic Peptide of Histone H1 (Phospho Ser1)
Specificity
The antibody detects endogenous Histone H1 (Phospho Ser1) protein.
Formulation
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Dilution rate
WB: 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Background
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015],
Function
function:Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.,similarity:Belongs to the histone H1/H5 family.,
Gene Name
HIST1H1A/HIST1H1C/HIST1H1D/HIST1H1E
Protein name
Histone H1.1/Histone H1.2/Histone H1.3/Histone H1.4
Other name
HIST1H1A; H1F1; Histone H1.1; Histone H1a; HIST1H1C; H1F2; Histone H1.2; Histone H1c; Histone H1d; Histone H1s-1; HIST1H1D; H1F3; Histone H1.3; Histone H1c; Histone H1s-2; HIST1H1E; H1F4; Histone H1.4; Histone H1b; Histone H1s-4
Human gene ID
3024/3006/3007/3008
Human protein sequence Database
Q02539/P16403/P16402/P10412
Mouse gene ID
80838/50708/14957/50709
Mouse protein sequence database
Rat gene ID
291145/201097
Rat protein sequence database
D4A3K5/P15865
Cellular localization
Nucleus . Chromosome . Mainly localizes in euchromatin.
Tissue expression
Placenta,
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