Molecular weight (DA)
70kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CCDC99. AA range:541-590
Specificity
CCDC99 Polyclonal Antibody detects endogenous levels of CCDC99 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a coiled-coil domain-containing protein that functions in mitotic spindle formation and chromosome segregation. The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins, and in mitotic checkpoint signaling. [provided by RefSeq, Jul 2016],
Function
mitotic sister chromatid segregation, M phase of mitotic cell cycle, establishment of mitotic spindle orientation,microtubule cytoskeleton organization, mitotic cell cycle, M phase, nuclear division, sister chromatid segregation, cell morphogenesis, cytoskeleton organization, microtubule-based process, cell cycle, chromosome segregation, mitosis,mitotic metaphase plate congression, establishment or maintenance of cell polarity, protein localization, cell cycle process, cell cycle phase, establishment of cell polarity, cellular component morphogenesis, protein localization to kinetochore, cellular protein localization, establishment of mitotic spindle localization, organelle fission, chromosome localization, chromosome organization, establishment of spindle localization, establishment of spindle orientation,establishment of chromosome localization, metaphase plate congression, organelle l
Protein name
Protein Spindly
Other name
CCDC99; Protein Spindly; hSpindly; Arsenite-related gene 1 protein; Coiled-coil domain-containing protein 99; Rhabdomyosarcoma antigen MU-RMS-40.4A
Human protein sequence Database
Q96EA4
Mouse protein sequence database
Q923A2
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.
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