Molecular weight (DA)
46kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CNOT2. AA range:67-116
Specificity
CNOT2 Polyclonal Antibody detects endogenous levels of CNOT2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
CCR4-NOT transcription complex subunit 2(CNOT2) Homo sapiens This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010],
Function
function:The CCR4-NOT complex functions as general transcription regulation complex.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CNOT2/3/5 family.,subunit:Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8.,tissue specificity:Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.,
Protein name
CCR4-NOT transcription complex subunit 2
Other name
CNOT2; CDC36; NOT2; HSPC131; MSTP046; CCR4-NOT transcription complex subunit 2; CCR4-associated factor 2
Human protein sequence Database
Q9NZN8
Mouse protein sequence database
Q8C5L3
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus .
Tissue expression
Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.
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