Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human DDX19B. AA range:1-50
Specificity
DDX19B Polyclonal Antibody detects endogenous levels of DDX19B protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:ATP-dependent RNA helicase involved in mRNA export from the nucleus.,similarity:Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subcellular location:Nuclear pore complex cytoplasmic fibrils.,subunit:Interacts with NUP214.,
Protein name
ATP-dependent RNA helicase DDX19B
Other name
DDX19B; DBP5; DDX19; TDBP; ATP-dependent RNA helicase DDX19B; DEAD box RNA helicase DEAD5; DEAD box protein 19B
Fields
>>Nucleocytoplasmic transport;>>mRNA surveillance pathway
Human protein sequence Database
Q9UMR2
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus, nucleoplasm . Associates with the nuclear pore complex cytoplasmic fibrils. .
Tissue expression
Brain,Liver,Ovary,Skin,Stomach,Testis,
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