Immunogen
Synthesized peptide derived from DDX54 . at AA range: 570-650
Specificity
DDX54 Polyclonal Antibody detects endogenous levels of DDX54 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.,similarity:Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subunit:Interacts in a hormone-dependent manner with nuclear receptors.,
Protein name
ATP-dependent RNA helicase DDX54
Other name
DDX54; ATP-dependent RNA helicase DDX54; ATP-dependent RNA helicase DP97; DEAD box RNA helicase 97 kDa; DEAD box protein 54
Human protein sequence Database
Q8TDD1
Mouse protein sequence database
Q8K4L0
Rat protein sequence database
Cellular localization
Nucleus, nucleolus .
Tissue expression
Expressed in the fallopian tube, cervix and uterus. Also expressed in the brain.
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