Molecular weight (DA)
63kD
Immunogen
The antiserum was produced against synthesized peptide derived from human DNA Polymerase lambda. AA range:451-500
Specificity
DNA pol λ Polyclonal Antibody detects endogenous levels of DNA pol λ protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010],
Function
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Manganese.,function:Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DNA polymerase type-X family.,similarity:Contains 1 BRCT domain.,subunit:Binds PCNA.,tissue specificity:Expressed in a number of tissues. Abundant in testis.,
Protein name
DNA polymerase lambda
Other name
POLL; DNA polymerase lambda; Pol Lambda; DNA polymerase beta-2; Pol beta2; DNA polymerase kappa
Fields
>>Base excision repair;>>Non-homologous end-joining
Human protein sequence Database
Q9UGP5
Mouse protein sequence database
Q9QXE2
Rat protein sequence database
Q5RKI3
Cellular localization
Nucleus . Chromosome . Accumulates at sites of DNA damage. .
Tissue expression
Expressed in a number of tissues. Abundant in testis.
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