Immunogen
The antiserum was produced against synthesized peptide derived from human EGR3. AA range:338-387
Specificity
Egr-3 Polyclonal Antibody detects endogenous levels of Egr-3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010],
Function
developmental stage:In T-cells, expressed 20 minutes following activation.,function:Probable transcription factor involved in muscle spindle development.,similarity:Belongs to the EGR C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,
Protein name
Early growth response protein 3
Other name
EGR3; PILOT; Early growth response protein 3; EGR-3; Zinc finger protein pilot
Fields
>>C-type lectin receptor signaling pathway;>>Hepatitis B;>>Viral carcinogenesis
Human protein sequence Database
Q06889
Mouse protein sequence database
P43300
Rat protein sequence database
P43301
Cellular localization
Nucleus .
Tissue expression
Brain,Peripheral blood T-cell,
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