Molecular weight (DA)
45kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GATA6. AA range:461-510
Specificity
GATA-6 Polyclonal Antibody detects endogenous levels of GATA-6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012],
Function
function:Thought to be important for regulating terminal differentiation and/or proliferation.,similarity:Contains 2 GATA-type zinc fingers.,tissue specificity:Expressed in heart, gut and gut-derived tissues.,
Protein name
Transcription factor GATA-6
Other name
GATA6; Transcription factor GATA-6; GATA-binding factor 6
Human protein sequence Database
Q92908
Mouse protein sequence database
Q61169
Rat protein sequence database
P46153
Cellular localization
Nucleus .
Tissue expression
Expressed in heart, gut and gut-derived tissues. Expressed in skin upper pilosebaceous unit. Expression is decreased or lost in acne lesions (PubMed:33082341).
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