Molecular weight (DA)
75kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HDAC10. AA range:10-59
Specificity
Histone deacetylase 10 Polyclonal Antibody detects endogenous levels of Histone deacetylase 10 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],
Function
catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,similarity:Belongs to the histone deacetylase family. Type 2 subfamily.,subcellular location:Excluded from the nucleoli.,subunit:Interacts with HDAC2, HDAC3 and NCOR2.,tissue specificity:Ubiquitous. High expression in liver, spleen, pancreas and kidney.,
Protein name
Histone deacetylase 10
Abbreviation
Histone deacetylase 10
Other name
HDAC10; Histone deacetylase 10; HD10
Fields
>>Neutrophil extracellular trap formation;>>Alcoholism;>>Viral carcinogenesis
Human protein sequence Database
Q969S8
Mouse protein sequence database
Q6P3E7
Rat protein sequence database
Q569C4
Cellular localization
Cytoplasm . Nucleus . Excluded from nucleoli. .
Tissue expression
Widely expressed with high levels in liver and kidney.
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