Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from human hnRNP L. AA range:61-110
Specificity
hnRNP L Polyclonal Antibody detects endogenous levels of hnRNP L protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different is
Function
function:This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. L is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes.,PTM:Several isoelectric forms of the L protein are probably the results of post-translational modifications.,similarity:Contains 3 RRM (RNA recognition motif) domains.,
Protein name
Heterogeneous nuclear ribonucleoprotein L
Other name
HNRNPL; HNRPL; P/OKcl.14; Heterogeneous nuclear ribonucleoprotein L; hnRNP L
Human protein sequence Database
P14866
Mouse protein sequence database
Q8R081
Rat protein sequence database
Cellular localization
Nucleus, nucleoplasm . Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules. .
Tissue expression
Brain,Cajal-Retzius cell,Fetal brain cortex,Keratinocyte,Pa
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