Molecular weight (DA)
25kD
Immunogen
Synthesized peptide derived from Mash2 . at AA range: 1-80
Specificity
Mash2 Polyclonal Antibody detects endogenous levels of Mash2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
achaete-scute family bHLH transcription factor 2(ASCL2) Homo sapiens This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008],
Function
function:AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein.,tissue specificity:Expressed specifically in the extravillous trophoblasts of the developing placenta.,
Protein name
Achaete-scute homolog 2
Other name
ASCL2; BHLHA45; HASH2; Achaete-scute homolog 2; ASH-2; hASH2; Class A basic helix-loop-helix protein 45; bHLHa45; Mash2
Human protein sequence Database
Q99929
Mouse protein sequence database
O35885
Rat protein sequence database
P19360
Cellular localization
Nucleus .
Tissue expression
Expressed specifically in the extravillous trophoblasts of the developing placenta.
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