Molecular weight (DA)
33kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Mlx. AA range:111-160
Specificity
Mlx Polyclonal Antibody detects endogenous levels of Mlx protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
Function
function:Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subcellular location:Found predominantly in the cytoplasm.,subcellular location:Found predominantly in the nucleus.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAD1, MAD4, MNT, WBSCR14 and MLXIP. Can also bind DNA as a homodimer.,tissue specificity:Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal
Protein name
Max-like protein X
Other name
MLX; BHLHD13; TCFL4; Max-like protein X; Class D basic helix-loop-helix protein 13; bHLHd13; Max-like bHLHZip protein; Protein BigMax; Transcription factor-like protein 4
Fields
>>Insulin resistance;>>Non-alcoholic fatty liver disease
Human protein sequence Database
Q9UH92
Mouse protein sequence database
O08609
Rat protein sequence database
Cellular localization
[Isoform Alpha]: Cytoplasm . Found predominantly in the cytoplasm (PubMed:10918583). .; [Isoform Beta]: Cytoplasm . Found predominantly in the cytoplasm (PubMed:10918583). .; [Isoform Gamma]: Nucleus . Found predominantly in the nucleus (PubMed:10918583). .
Tissue expression
Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung.
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