Molecular weight (DA)
22kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Musculin. AA range:131-180
Specificity
Musculin Polyclonal Antibody detects endogenous levels of Musculin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008],
Function
function:Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer. Forms a heterodimer with TCF3.,tissue specificity:Expressed in lymphoid tissues, B-cell lines and activated B-cells.,
Other name
MSC; ABF1; BHLHA22; Musculin; Activated B-cell factor 1; ABF-1; Class A basic helix-loop-helix protein 22; bHLHa22
Human protein sequence Database
O60682
Mouse protein sequence database
O88940
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Expressed in lymphoid tissues, B-cell lines and activated B-cells.
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