Molecular weight (DA)
35kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NANOGP8. AA range:51-100
Specificity
Nanog P8 Polyclonal Antibody detects endogenous levels of Nanog P8 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000; IF/ICC 1:50-200;ELISA 1:2000-20000;IHC-p 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This locus is a processed pseudogene of the transcription factor NANOG. NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells. This pseudogene contains an intact open reading frame that could potentially encode a protein similar to NANOG. Although there is no evidence of transcription from this pseudogene, RT-PCR studies suggest that NANOGP8 may be expressed in some cancer cell lines. In vitro studies using a recombinant NANOGP8 protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to NANOG. [provided by RefSeq, Sep 2009],
Function
developmental stage:Expressed in embryonic stem (ES) and carcinoma (EC) cells. Expressed in inner cell mass (ICM) of the blastocyst and gonocytes between 14 and 19 weeks of gestation (at protein level). Not expressed in oocytes, unfertilized oocytes, 2-16 cell embryos and early morula (at protein level). Expressed in embryonic stem cells (ES). Expression decreases with ES differentiation.,function:May act as a transcription regulator (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation.,function:Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 an
Protein name
Putative homeobox protein NANOGP8
Other name
NANOGP8; Putative homeobox protein NANOGP8
Fields
>>Signaling pathways regulating pluripotency of stem cells;>>Proteoglycans in cancer
Human protein sequence Database
Q6NSW7
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Embryonic stem cell,Teratocarcinoma,Urinary bladder carcinoma,
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