Molecular weight (DA)
35kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NEIL3. AA range:491-540
Specificity
NEIL3 Polyclonal Antibody detects endogenous levels of NEIL3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008],
Function
function:Reports about DNA glycosylase activity are contradictory. The protein lacks a proline residue at the N-terminus that is the active site residue found in the other members of the FPG family.,similarity:Belongs to the FPG family.,similarity:Contains 1 FPG-type zinc finger.,similarity:Contains 1 RanBP2-type zinc finger.,tissue specificity:Detected in thymus and testis.,
Protein name
Endonuclease 8-like 3
Other name
NEIL3; Endonuclease 8-like 3; DNA glycosylase FPG2; DNA glycosylase/AP lyase Neil3; Endonuclease VIII-like 3; Nei-like protein 3
Fields
>>Base excision repair
Human protein sequence Database
Q8TAT5
Mouse protein sequence database
Q8K203
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Recruited to replication stress sites via interaction with ubiquitinated CMG helicase. .
Tissue expression
Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts.
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