Molecular weight (DA)
82kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SP3/4. AA range:671-720
Specificity
Sp3/4 Polyclonal Antibody detects endogenous levels of Sp3/4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010],
Function
function:Transcriptional factor that can act as an activator or repressor, probably in a isoform-specific manner. Binds to GT and GC boxes promoters elements.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,tissue specificity:Ubiquitously expressed.,
Protein name
Transcription factor Sp3/4
Other name
SP3; Transcription factor Sp3; SPR-2; SP4; Transcription factor Sp4; SPR-1
Human protein sequence Database
Q02447/Q02446
Mouse gene ID
20687/20688
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus. Nucleus, PML body. Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.
Tissue expression
Ubiquitously expressed.
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