Molecular weight (DA)
58kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TBX22. AA range:1-50
Specificity
TBX22 Polyclonal Antibody detects endogenous levels of TBX22 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
T-box 22(TBX22) Homo sapiens This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
disease:Defects in TBX22 are the cause of X-linked cleft palate with ankyloglossia (CPX) [MIM:303400].,function:Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:Seems to be expressed at a low level.,
Protein name
T-box transcription factor TBX22
Other name
TBX22; TBOX22; T-box transcription factor TBX22; T-box protein 22
Human protein sequence Database
Q9Y458
Mouse protein sequence database
Q8K402
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Seems to be expressed at a low level.
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