Molecular weight (DA)
79kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TBX3. AA range:301-350
Specificity
TBX3 Polyclonal Antibody detects endogenous levels of TBX3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008],
Function
disease:Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS) [MIM:181450]. UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands.,function:Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:Widely expressed.,
Protein name
T-box transcription factor TBX3
Other name
TBX3; T-box transcription factor TBX3; T-box protein 3
Fields
>>Signaling pathways regulating pluripotency of stem cells
Human protein sequence Database
O15119
Mouse protein sequence database
P70324
Rat protein sequence database
Q7TST9
Cellular localization
Nucleus .
Tissue expression
Widely expressed.
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