Molecular weight (DA)
110kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TLE2. AA range:211-260
Specificity
TLE2 Polyclonal Antibody detects endogenous levels of TLE2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 6 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5.,tissue specificity:In all tissues examined, mostly in heart, brain, and muscle.,
Function
function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 6 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5.,tissue specificity:In all tissues examined, mostly in heart, brain, and muscle.,
Protein name
Transducin-like enhancer protein 2
Other name
TLE2; Transducin-like enhancer protein 2; Enhancer of split groucho-like protein 2; ESG2
Fields
>>Wnt signaling pathway;>>Notch signaling pathway
Human protein sequence Database
Q04725
Mouse protein sequence database
Q9WVB2
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
In all tissues examined, mostly in heart, brain, and muscle.
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