Molecular weight (DA)
108kD
Immunogen
The antiserum was produced against synthesized peptide derived from human XRN2. AA range:81-130
Specificity
XRN2 Polyclonal Antibody detects endogenous levels of XRN2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015],
Function
catalytic activity:Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates.,function:Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription.,similarity:Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.,similarity:Contains 1 CCHC-type zinc finger.,tissue specificity:Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2
Protein name
5'-3' exoribonuclease 2
Other name
XRN2; 5'-3' exoribonuclease 2; DHM1-like protein; DHP protein
Fields
>>Ribosome biogenesis in eukaryotes;>>RNA degradation
Human protein sequence Database
Q9H0D6
Mouse protein sequence database
Q9DBR1
Rat protein sequence database
Cellular localization
Nucleus, nucleolus .
Tissue expression
Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.
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